Publication at First Faculty of Medicine |
2014
Abstract
Galectins are representatives of endogenous lectins - molecules specifically recognizing distinct sugar motifs. They play an important role in the processes of cell proliferation, differentiation, migration and extracellular matrix formation.
Furthermore, galectins are able to transfer cellular signals and to participate in intercellular interaction. It has been proven that galectins play an important role in the formation of tumour and/or wound healing microenvironment.
This review contains an overview of experimental and clinical studies dealing with biological roles of galectins in tissue repair and in its parallel - the tumor growth.