The PRIMARA study: a prospective, descriptive, observational study to review cinacalcet use in patients with primary hyperparathyroidism in clinical practice
Abstrakt
Objective Medical management of primary hyperparathyroidism (PHPT) is important in patients for whom surgery is inappropriate. We aimed to describe clinical profiles of adults with PHPT receiving cinacalcet.
Design A descriptive, prospective, observational study in hospital and specialist care centres. Methods For patients with PHPT, aged 23-92 years, starting cinacalcet treatment for the first time, information was collected on dosing pattern, biochemistry and adverse drug reactions (ADRs).
Initial cinacalcet dosage and subsequent dose changes were at the investigator's discretion. Results Of 303 evaluable patients with PHPT, 134 (44%) had symptoms at diagnosis (mostly bone pain (58) or renal stones (50)).
Mean albumin-corrected serum calcium (ACSC) at baseline was 11.4 mg/dl (2.9 mmol/l). The reasons for prescribing cinacalcet included: surgery deemed inappropriate (35%), patient declined surgery (28%) and surgery failed or contraindicated (22%).
Mean cinacalcet dose was 43.9 mg/day (s.d., 15.8) at treatment start and 51.3 mg/day (31.8) at month 12; 219 (72%) patients completed 12 months treatment. The main reason for cinacalcet discontinuation was parathyroidectomy (40; 13%).
At 3, 6 and 12 months from the start of treatment, 63, 69 and 71% of patients, respectively, had an ACSC of LESS-THAN OR EQUAL TO10.3 mg/dl vs 9.9% at baseline. Reductions from baseline in ACSC of GREATER-THAN OR EQUAL TO1 mg/dl were seen in 56, 63 and 60% of patients respectively.
ADRs were reported in 81 patients (27%), most commonly nausea. A total of 7.6% of patients discontinued cinacalcet due to ADRs.
Conclusions Reductions in calcium levels of GREATER-THAN OR EQUAL TO1 mg/dl was observed in 60% of patients 12 months after initiation of cinacalcet, without notable safety concerns.