Abstract
A series of 27 salicylanilide diethyl phosphates was prepared as a part of our on-going search for new antimicrobial active drugs. All compounds exhibited in vitro activity against Mycobacterium tuberculosis, Mycobacterium kansasii and Mycobacterium avium strains, with minimum inhibitory concentration (MIC) values of 0.5-62.5 mu mol/L.
Selected salicylanilide diethyl phosphates also inhibit multidrug-resistant tuberculous strains at the concentration of 1 mu mol/L. Salicylanilide diethyl phosphates also exhibited mostly the activity against Gram-positive bacteria (MICs }= P1.95 mu mol/L), whereas their antifungal activity is significantly lower.
The IC50 values for Hep G2 cells were within the range of 1.56-33.82 mu mol/L, but there is no direct correlation with MICs for mycobacteria.