Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands

Abstract

Polymorphous low-grade adenocarcinoma (PLGA) is the second most frequent type of malignant tumor of the minor salivary glands. We identified PRKD1 hotspot mutations encoding p.Glu710Asp in 72.9% of PLGAs but not in other salivary gland tumors.

Functional studies demonstrated that this kinase-activating alteration likely constitutes a driver of PLGA.

Keywords

• hotspot activating PRKD1 somatic mutations
• polymorphous low-grade
• adenocarcinoma
• salivary glands