Adjustment of therapy in rheumatoid arthritis on the basis of achievement of stable low disease activity with adalimumab plus methotrexate or methotrexate alone: the randomised controlled OPTIMA trial

Abstract

Randomised, controlled study in two phases. In first open phase were all patients treated by full dose of adalimumab.

After reaching low disease activity patients were randomized in group which continue in therapy with anti TNF and group were biological drug was withdrawn

Keywords

• rheumatoid arthritis
• biologic therapy