Cyclin D1 splice site variant triggers chromosomal aberrations in healthy humans

Abstract

Chromosomal aberrations (CAs) were suggested to be the cause of cancer by Boveri already a 100 years ago, but the detection of the Philadelphia chromosome about 50 years later provided the first direct evidence on the relationship.

Keywords

• multiple-myeloma
• cancer
• lymphocytes
• damage
• risk
• translocations
• polymorphism