Abstract
Objective: To investigate the predictive factors of insufficient endometrial quality. Design: Review.
Setting: Department of Obstetrics and Gynecology, General Faculty Hospital Prague, 1st Faculty of Medicine, Charles University. Results: This is the review on predictive factors of endometrial receptivity.
There is a collected data on homeobox genes family, especially HOX 10 and HOX 11 members, that ensure implantation process by means of their interaction with estrogen and progesterone receptors via stimulatory proteins in the luminal epithelium in different periods of luteal phase. Moreover, the article describes appropriate secretion of osteoponin, cadherin, selectin, apopoliprotein D, mucin and balanced macrophage activity in endometrial epithelium in the proliferative phase of the menstrual cycle provide optimal conditions for implantation.
Conclusion: Endometrial genes expressions along with the intrauterine environment macrophages activity maintain the tiny mechanism of endometrial receptivity