Serum S100a4 Correlates with Skin Fibrosis, Lung Involvement and Disease Activity in Systemic Sclerosis
Abstract
Objectives To evaluate S100A4 in sera of SSc patients and characterise its potential association with SSc-related features. Conclusions We demonstrate that S100A4 serum levels are significantly increased in SSc patients compared with healthy controls.
Higher levels of S100A4 are associated with dcSSc subset, skin involvement, deteriorated parameters of lung involvement and higher disease activity. These data support our previous findings on the role of S100A4 as a regulator of TGF-β induced fibroblast activation and dermal fibrosis in SSc.