Progressive Dementia with Parkinsonism and Behavioral Changes - from the First Manifestations to the Neuropathological Confirmation (a Case Study)
Abstract
We describe a case of a 69-year-old man with an atypical course of dementia with Parkinsonism and progressive severe behavioral abnormalities. Clinical presentation was compatible with dementia with Lewy bodies or frontotemporal dementia with Parkinsonism.
The rapid and atypical progression was related to neuropathological findings of two co-morbid neurodegenerative entities. Fully developed dementia with Lewy bodies predominated, while markers of Alzheimer's disease were also present in the brain tissue.
However, their less expressed and more widespread distribution was probably related to the absence of clinical manifestations of progressive amnestic dementia, a typical symptom of Alzheimer's disease. We retrospectively completed missing data and retraced the clinical course from the first disease manifestations to the definite neuropathological diagnosis.