Abstract
Ischemic disease of lower extremities is a significant manifestation of systemic atherosclerosis. The cornerstone of its treatment is formed by aggressive interventions of known risk factors - smoking, dyslipoproteinemia, arterial hypertension, and diabetes.
Risk factors should be intervened using medicaments even in asymptomatic individuals. Antiplatelet drugs, statins, and angiotensin-converting enzyme (ACE) inhibitors (or telmisartan) are used in order to improve the global cardiovascular prognosis of patients.
Vasoactive drugs, especially cilostazol and naftidrofuryl, are given to alleviate the symptoms of the disease, i.e. to prolong the claudication distance. As for non-pharmacological interventions, claudications can be influenced in a significant positive way by dosed muscle training, ideally under the supervision of rehabilitation specialists - but even without it.