Fine tuning of surface CRLF2 expression and its associated signaling profile in childhood B-cell precursor acute lymphoblastic leukemia
2015
Abstract
Genomic rearrangements of the cytokine receptor-like factor 2 (CRLF2) gene,which is part of the thymic stromal lymphopoietin receptor (TSLPR), result in overexpression of CRLF2 itself leading to JAK2-mediated activation of STAT5, which regulates cell proliferation, survival, and apoptosis. In this regard, childhood B-cell precursor acute lymphoblastic leukemias (BCP-ALLs), bearing a rearranged CRLF2, display a high rate of relapse.5-10 Furthermore, CRLF2 genomic rearrangements are strictly associated with its surface overexpression, rendering this marker suitable for detection by flow cytometry (FCM).