Abstract
Chronic pancreatitis (ChP) is a progressive inflammatory disorder characterized by the destruction of parenchyma that is replaced by fibrous tissue. There is evidence that deregulation of fatty acid (FA) metabolism is connected with a number of diseases.
We decided to analyze profile of FA in plasma lipid classes in patients with ChP, with 2 type diabetes mellitus (DM) and healthy people. Pattern of FA is affected by many factors including starvation, dietary intake and various pathological states.
The aim of the study was to analyze FA pattern in all lipid classes in all groups of patients, to elicit eventual deficiency of essential FA and to detect relationship between clinical or biochemical disturbances and FA profile. Patients with ChP (n = 21), patients with ChP + DM type 3c (n = 45), and 90 healthy persons were included in the study.
Anthropometric and biochemical parameters were examined by conventional methods. Profile of FA in plasma lipids was determined by capillary gas chromatography.
Increased proportion of total monounsaturated FA (MUFA) in all patient groups as well as in all plasma lipid classes was observed. We proved elevations of pamitoleic, oleic and vaccenic acids.
These changes were connected with increased Δ9-desaturase of palmitic and oleic acids. We found decreased sum of n-6 polyunsaturated FA (PUFA), especially linoleic acid, in ChP group.