Detection of dasatinib using pre-reaction with copper and mass spectrometry

Abstract

The determination of dasatinib (DAS) was provided using front- end electrochemical separation with mass detection. The electrochemical separation is based on the reaction of DAS with copper solid electrode.

The affinity of DAS to copper is supported by redox reaction leading to DAS fragmentation.

Keywords

• Electrochemical separation
• Hyphenation
• EC-ESI-MS
• Copper