Expanding the scope of Metal-Free enantioselective allylic substitutions: Anthrones

Abstract

The highly enantioselective asymmetric allylic alkylation of Morita-Baylis-Hillman carbonates with anthrones is presented. The reaction is simply catalyzed by cinchona alkaloid derivatives affording the final alkylated products in good yields and excellent enantioselectivities.

Keywords

• baylis-hillman carbonates
• asymmetric cycloaddition
• c-2-chiral pyrrolidines
• michael addition
• maleimides
• hypericin
• derivatives
• dienophiles
• inhibition
• precursors