Abstract
Ustekinumab is a fully human IgG1κ monoclonal antibody that inhibits interleukin 12 and 23 functions by binding to their p40 subunit. Ustekinumab is used in treating moderate and severe form of dermal psoriasis; however, a number of clinical studies have shown its effect on extradermal manifestations, particularly on the musculoskeletal system.
PSUMMIT-1 and -2 clinical studies in patients with psoriatic arthritis have demonstrated good properties of ustekinumab for inducing a rapid therapeutic response with a good safety profile, and allowed registration for this indication as well.