Abstrakt
We developed an biodegradable polymeric mucoadhesive system based on the solid molecular dispersion of drug and branched poly(lactic-co-glycolic)acid copolymer. The drug incorporation was carried out either by dissolution of both components in methyl formate followed by its evaporation, or by plasticization using different plasticizers.
The polymeric system formulated by our team offers several benefits: i) increased solubility of moleculary dispersed drug in amorphous polymer, ii) excellent adhesion to hydrophilic surfaces thanks to mucoadhesive properties of branched polyestr carrier, iii) prolonged drug release iv) supportive healing and anti-inflammatory effects given by the presence of ethyl pyruvate as multifunctional plasticizer, v) consistency can be adjusted to fit different methods of application (sticking, smearing, spraying) by changing plasticizer concentration.