MoM-based Approach to Noninvasive Prenatal Testing Using Exponentially Weighted Moving Average Chart and Chromosomal Fingerprint
2015
Abstract
The cohort for this study consisted of 272 women with singleton pregnancies and known fetal karyotype. The cohort was divided into two groups.
Group I, which included 93 pregnancies with euploid fetuses, was used to construct reference range. Groups II, which consisted of 179 pregnancies (145 with euploid fetuses, 3 with fetuses with trisomy 13, 9 with trisomy 18 and 22 with trisomy 21) was used as a testing group to assess the suggested approach.
The new MoM-based approach using chromosomal fingerprint and EWMA has a high performance in noninvasive aneuploidy screening with high sensitivity and low false positivity.