The aim of this article (and the special issue as a whole) is to re-introduce "symmetrical anthropology" in the Czech social scientifi c milieu as a research programme worth pursuing. Contrary to accusations of Latour's work, and Actor-Network Th eory more generally, of political naïveté, if not conservatism, we understand symmetrical anthropology as a challenging incentive to study our world of multiple asymmetries: social, economic, geopolitical, biological, communicational.