Abstract
Wolf's isotopic response describes the appearance of an altogether different disease at the site of an already healed or still present skin disease. While the primary disease is most often herpes zoster and herpes simplex, various dermatoses appear as the secondary skin disease.
There are 191 published cases od Wolf's isotopic postherpetic response. Reports describe granulomatous reactions, malignant tumors, lymphocytic and leukemic infiltrations, lichen planus, lichen sclerosus and atrophicus, infections (viral, bacterial, mycotis), acneiform eruptions and others.
Authors report a case of granuloma anulare isotopic response, which is the most common type of reaction, at the site of healed herpes zoster in a patient with chronic lymphatic leukemia.