Epithelial markers of colorectal carcinogenesis in ulcerative colitis and primary sclerosing cholangitis

Abstract

Our study shows that the nondysplatic mucosa of UC patients with PSC is characterised by a higher expression of the tumour suppressor gene p53, suggesting a higher susceptibility of cancer. This p53 overexpression correlates with the presence of PSC whilst it is not present in patients with UC after liver transplantation for PSC.

Keywords

• Imunohistochemistry
• Ulcerative colitis
• Primary sclerosing cholangitis
• Colorectal carcinoma
• Liver transplantation
• p53
• bcl2
• Cyclooxygenase-2