Abstract
In light of current knowledge, combination therapy of hypertension involving, in particular, the administration of drugs affecting the renin-angiotensin-aldosterone system, calcium channel blockers, and diuretics in fixed combinations represents a gold standard. Due to different mechanisms of action of the individual agents, these combinations of antihypertensive drugs have a significant additive and synergic antihypertensive effect leading to a more pronounced reduction in blood pressure and lower rates of adverse events of the individual components.
Prescription of fixed combinations also increases patient compliance. Moreover, selection of a wide range of doses of the individual components allows their administration to patients with various degrees of arterial hypertension.