Abstract
Administration of the intramuscular injection of benzathine benzylpenicillin (benzathine PNC G) is associated with pain or discomfort, which could lead to non-adherence to the therapy. This risk may be even greater in children and adolescents, therefore, it is desirable to minimize the pain, especially when medications containing benzathine PNC G alongside with other ingredients relieving pain are not registered and commercially unavailable.
This paper reviews evidence of published literature, describing two alternatives which could be also employed in paediatric practice to alleviate the pain. Firstly, the procedure of mixing two available medicinal products containing benzathine and procaine PNC G, secondly, the use of a lidocaine solution for reconstitution of benzathine PNC G powder for injection.
Reported evidence suggests both options are safe and does not lead to decrease in PNC G serum concentrations. Finally, a case study is described demonstrating our clinical experience.