Abstrakt
Background: Human papillomaviruses (HPV) are a heterogeneous group of viruses classified into five genera. The beta-HPV type (beta-PV) infection is very common but mostly asymptomatic in immunocompetent individuals.
However, beta-PVs play a role in Epidermodysplasia verruciformis and possibly in non-melanoma skin cancer. Head and neck cancer (HNC) is a common cancer type worldwide and high-risk alpha-PV involvement in HNC has been extensively studied but beta-PV types have rarely been the focus of such studies.
Objectives: To evaluate the prevalence of beta-PV types in HNC, subjects with non-malignant or potentially pre-malignant oral lesions, and healthy controls. Study design: The frequency of different beta-PVs in samples from oral (n = 35) and oropharyngeal (n = 35) cancer patients, gender-and age-matched healthy controls (n = 70), and subjects with various non-malignant or potentially pre-malignant oral lesions (n = 102) was assessed by a highly sensitive, bead-based, multiplex genotyping assay.
Results: Overall, 54.8% of all tested samples contained at least one beta-PV type. Even though the correlation between types found in lavage and tissue specimens from cancer patients was low, there was a large statistically significant difference between oropharyngeal cancer patients and matched controls for HPV5 (P = 0.003; OR=15.58) and between both oral (P = 0.026; OR= 5.7) and oropharyngeal cancer patients (P=0.002; OR=25.5) and controls for HPV122.
In addition, there was no correlation between the prevalence of alpha and beta-PVs in the study patients. Conclusion: The study provides new data on the prevalence of beta-PVs in HNC.
HPV5 was found significantly associated with HNC as already observed by other studies. Additionally, the significant association of HPV122 with HNC might warrant further study as this type has not been extensively studied so far.