Laser-assisted transdermal drug delivery (DADD-Device Assisted Drug Delivery ) -new universe not only for Dermato-venereology
Abstract
The transdermal drug delivery, if possible at all, it usually reaches a low efficiency of 1-5%, which is due to the key protective function of the skin barrier. We have a variety of physical methods, as this efficiency increase.
One possibility is forced penetration of drug molecules (iontophoresis, electrophoresis, sonophoretic, increased pressure), the second is disruption of the skin barrier (micro-needling). However, only the use of radiofrequency and particularly lasers enable far the highest efficiency with consecutive predictability.
Laser (device) assisted drug delivery (DADD) offers entirely new possibilities of efficient topical administration of a variety of substances (cytostatic, photodynamic therapy, corticosteroids, vitamins, anaesthetics, but also insulin or antihypertensive). Efficiency is high enough that many substances have even at a low amount of the administered volume significant systemic effect, which represents a waste number of new opportunities but also the possible side-effects.