Abstract
In last years the understanding of energy substrate metabolism significantly has changed. Most important changes are postulated in the following principles: 1.
Metabolic energy production is not closely dependent on just one energy substrate (glucose, fatty acid, amino acid). 2. Exceptional is position of ketone bodies utilizable even in serious stress, when oxidation of glucose, fatty acids and amino acids is suppressed. 3.
Favourable metabolic effect and availability of nutritional substrates depends on the organ energy requirement changed in critical condition and on the tissue perfusion and oxygen delivery.