Blood-Pool Compensation Method Revisited: Similarity and Difference in Comparison with Patlak-Rutland Plot

Abstract

A slope of Patlak-Rutland plot as been used to calculate differential kidney function not affected by vascular background in the kidney ROI. Blood-pool compensation method claims that it further corrects for extravascular background.

The aim of this study was to examine the assertion in more detail. Method: Performance of PRP and BPC has been compared with simulated and patient data.

Renal curves were simulated as "zero-output curves" - scaled integrals of a monoexponential plasma clearance curve. Vascular backgrounds were simulated as scaled plasma curves, extravascular backgrounds as weak kidneys.

In the patient data, PRP and BPC were applied to a fixed interval between 1 - 2 minutes. Both the heart and the liver ROIs have been used to generate input functions and a circumferential kidney ROI was chosen to represent kidney background.

Differential kidney functions calculated by PRP and BPC under various conditions were compared using Passing-Bablok regression.