Characterization of Enterococcus faecium CCDM 922 in respect of its technological and probiotic properties
Abstract
The aim of this study was to characterize the adherence, immunomodulatory and other health properties and safety of Enteroccoccus faecium CCDM 922 from the Culture Collection of Dairy Microorganisms Laktoflora(R). E. faecium CCDM 922 is susceptible to therapeutically important antibiotics and exhibits good adherence to Caco-2 cells (52.33 +- 10.11 %).
Two different concentrations of E. faecium CCDM 922 were used for three and five-day stimulation of human mononuclear cells obtained from peripheral blood. Levels of IFN-γ, IL-6, IL-10, IL-17 and IL-1α were dependent on the density of E. faecium CCDM 922 used for stimulation and on time of stimulation.
The cholesterol-lowering effect of E. faecium CCDM 922 was tested in Prague hereditary hypercholesterolemic rats. E. faecium CCDM 922 treatment of male rats reduced LDL- and VLDL-cholesterol levels significantly (P < 0.05).
Present results indicated promising probiotic and technological potential for application of E. faecium CCDM 922 in functional foods or dairy products.