Abstract
Autoimmune and/or isoimmune infertility can be caused also by sperm antibodies, which are able to stop in vitro and in vivo sperm progressive penetration needed for fertility. This chapter covers all aspects concerning male and female antibody and cellular immunological disorders to spermatozoa complicating human fertility, and possible ways of the treatment.
Regarding the incidence of sperm antibodies in an infertile population, which is 9 % of the men and 15 % of the women, it is necessary to define significant sperm antigens for desensitization of immunological infertility and/or for development of contraceptive treatment.