Review of Current Guidelines for Systemic "Non-biological" Therapy of Psoriasis: Clinical Practice Guidelines of the Board of ČDS ČLS JEP
Abstract
Psoriasis is a chronic genetically determined immunologically mediated inflammatory condition with important systemic component (cardiovascular diseases, metabolic syndrome etc.(. Local therapy and phototherapy is usually recommended for mild psoriasis.
When this treatment is not effective, not tolerated or contraindicated, as well as in patients with severe disease or significantly decreased quality of life the systemic therapy is prescribed. Current range of systemic therapy in the Czech Republic includes non-biological agents (methotrexate, ciclosporin, acitretin), phototherapy and biological agents (adalimumab, etanercept, infliximab, ustekinumab, secukinumab).
Presented recommendation for "non-biological" systemic therapy of adult patients with moderate to severe psoriasis takes into account the European guidelines published in 2009 and their revised version from the year 2015 and international consensus adjusted upon clinical practice in the Czech Republic and current drug paskage inserts information (SPC).