Publication at Second Faculty of Medicine, Faculty of Medicine in Hradec Králové |
2017
Abstract
Nephrotic syndrome is caused by increased permeability of glomerular filtration barrier, which results in heavy proteinuria, hypoproteinemia and edemas. The most common form in children is idiopathic nephrotic syndrome, which is further classified according to therapuetic response to corticosteroids.
Other immunosupressants (levamisol, cyclophosphamide, cyclosporin A, mycophenolate mofetil) and monoclonal antibodies (rituximab, ofatumumab) are used as steroid sparing agents in the management of complicated cases. Advances in molecular genetics and understanding of podocyte pathophysiology changed the approach and management of hereditary nephrotic syndrome.