Abstract
Monoclonal antibody therapy is a form of immunotherapy that uses monoclonal antibodies to bind monospecifically to certain proteins or cells. This may then stimulate the patient's immune system to attack those targets.
About 50 monoclonal antibodies are currently accepted for clinical use as therapeutics, with many others been at various trial stages. Therapeutic monoclonal antibodies display an interindividual variability in their efficacy and side effects, which must be taken into consideration in clinical praxis.
Biological monitoring of serum drug levels and antibodies to these drugs allowing for individualized prescription and dose adjustments may lead to therapeutic optimization and limitation of the high costs of this kind of treatment.