Abstract
Background: A drug-related problem (DRP) is any problem associated with pharmacotherapy that hinders the achievement of treatment goals. As a result, there may be an inadequate effect and undesirable treatment response.
DRPs occur quite often in clinical practice. They can aggravate the patient's health and lead to the increased health care costs.
Objective: The aim of this paper was to show the example of DRP management on two patients after kidney transplantation and to discuss the optimization of pharmacotherapy in this group of patients. Methods: The prospective cross-sectional study, approved by the ethics committee, was undertaken at the Hemodialysis Center in the Teaching Hospital Hradec Králové.
From March 2016 to March 2017, the trained pharmacist performed structured interview with 211 randomized kidney transplant patients and reviewed their medication records. The identified DRPs were categorized according to the modified PCNE classification V5.01.
The SAZE algorithm was used to analyze DRPs and evaluate their clinical significance. Two case reports were selected from the obtained data, which were described and discussed in the present paper.
Results: Two model case reports were presented. In the first case report, 9 DRPs were identified, in the second 6 DRPs.
The analysis was mainly focused on antihypertensive therapy and antiplatelet treatment in the primary prevention of cardiovascular diseases. Conclusion: Interdisciplinary cooperation can lead to the optimization of pharmacotherapy.