In the first part of the book Thus Spoke Zarathustra Nietzsche speaks of two kinds of selfishness: on the one side, there is the low and limited egoism, on the other, the pure giving of himself, the bestowed love. This new virtue creates new values that replace the original virtues of the weak.
So Zarathustra himself has to overcome his last weakness, his pity. Against two types of selfishness, there are two different ways of overcoming pity.
One way is its absolute rejection when this emotion is to be removed as a degenerating, non-powerful, perverse, and diminishing man. As a second way, an interpretative option is offered to overcome compassion in the sense of his re-evaluation, transformation, dominion and reconciliation, when the candidate for such an analogous availability seems to be the bestowed virtue.