Publication at First Faculty of Medicine |
2017
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary disease of the kidney. Besides the renal manifestation, the extrarenal complications can be really dangerous, Developing methods of molecular genetics enable the presymptomatic diagnosis and establishment of the disease prognosis.
ADPKD often terminates in end stage renal failure in the fifth or sixth decade. Nowadays, the symptomatic therapeutic possibilities such as huge water daily intake and strict blood pressure control are available, The availability of new drugs (e.g. tolvaptan, somatostatin derivates), which can prolong the life without end stage Ienal failure, will come into account in a near future.