Progress report of project realization "Morpholine inhibitors of DNA-dependent protein kinase as a potential radio-and chemosensitizing agent of tumor cells "
Abstract
The goal of the project is to determine IC50 to DNA-PK and to four PI3K isoforms (α, β, γ and δ), to determine chemosenzitization using kampothecin or etoposide, to analyze cell cycle affects including apoptosis with using flow cytometry.