Singh Ospina, N., Maraka, S., Espinosa DeYcaza, A., O'Keeffe, D., Brito, J. P., Gionfriddo, M. R., Castro, M. R., Morris, J. C., Erwin, P., Montori, V. M.:Diagnostic accuracy of thyroid nodule growth to predict malignancy in thyroid nodules with benign cytology: systematic review and meta-analysis
2017
Abstract
The objective of this study was to summarize the evidence regarding the diagnostic accuracy of growth during follow-up of benign thyroid nodules for thyroid cancer. The body of evidence linking nodule growth with thyroid cancer during the follow-up of benign nodules warrants very low confidence.
In the era of high-value health care, the commonplace practice of following benign thyroid nodules with serial ultrasound assessment of growth to diagnose cancer can be questioned, calling for imminent evaluation.