Abstract
Previous WHO classification of tumors of the central nervous system were histogenetic, diagnostic entities were defined only by histomorphology. In the last classification it is for the first time that molecular genetic markers are directly incorporated into the definition of seberal diagnostic entities.
This so-called integrated diagnosis links both the histologic and genetic features for the diagnosis of several tumors. New entities that are defined by histology and molecular features are IDH-wild-type and IDH-mutant glioblastoma, H3 K27M-mutant diffuse midline glioma, RELA fusino-positive ependymoma, WNT-activated and SHH-activated medulloblastoma and C19MC alterated embryonal tumor with multilayered rosettes.
Last WHO classification from 2016 should be for the brain tgumor diagnostics mandatory.