Abstract
Background: The ischemia/reperfusion process in the course of acute coronary syndrome with ST-segment elevation is associatedwith significant increase of immune system activation. CD163 molecule belongs to important parts of the scavenger system,which helps to eliminate hemoglobin-haptoglobin complex and has the potential to suppress reactive oxygen radicals production.
Aim: The aim of our study was to assess sCD163 level in the course of STEMI.Patients and method: Plasma sDC163 level was assessed in a group of 29 patients (25 males, 4 females) of average age 64.5 let+- 7.5 yrs. at the time of admission, at 24 hours and at 96 hours. Results: The plasma sCD163 level was increasing during the time of observation [0h: 1770.5 (1451; 2096.25) μg/L vs. 1178 (1078;1265) μg/L, p < 0.001, 24h: 2063 (1589; 2453) vs. 1178 (1078;1265) μg/L, p < 0.001, 96h: 2116 (1924; 2458) vs. 1178 (1078; 1265) μg/L, p < 0.001].
Plasma sCD163 level was associated with leftventricle ejection fraction. Conclusion: The study showed a potential significance of sCD163 assessment as a prognostic marker.