Variceal bleeding is one of the severest life threatening complications of portal hypertension. Appropriate treatment includes initial general management, fluid replacement and hemo-substitution, antibiotic prophylaxis, vasoactive medication, and endoscopic treatments.
A transjugular intrahepatic portosystemic shunt (TIPS) is indicated in cases of failure. A dedicated esophageal metal stent or balloon tamponade is sometimes used as a "bridge" to TIPS placement or in cases of TIPS contraindications.
Non-selective β-blockers and endoscopic therapy are used in primary and secondary prophylaxis. The following paper summarises the update to the recommendation of the Czech Society of Hepatology for this treatment.