The paper recalls the significance of Lorenz Oken (1779-1851) and the journal Isis that he founded and led in 1817-1848. It characterises Oken's compentence and leading role in the framework of the German idealistic Naturphilosophie movement, and informs briefly of his professional activity.
It is further devoted to the significance of the journal Isis for the historiography of science and also to its relation to the Czech science, namely to Jan Evangelista Purkyně (1787-1869) and to Georg Franz August Graf von Buquoy (1781-1851), aristocrat, mathematician, inventor and natural philosophy polyhistor.