Abstract
Hand in hand with expansion of the original dopamine hypothesis of schizophrenia to other psychotogenic mechanisms including serotonergic, glutamatergic and cholinergic neurotransmission, broadens the range of potential antipsychotic therapeutic modalities. One of the important additional factors in pathogenesis of psychosis is apparently encounter with infection, which is involved in the morphological changes observed in schizophrenia.
Psychotogenic effects are exerted mainly by quinolinic acid, which is increasingly formed due to the immune modification of the tryptophan metabolic pathway. Antipsychotic aripiprazole exerts interesting immunomodulatory effects, which encourage first, to search for the antipsychotic effect of immunomodulation, and second, to test similar effects of other currently used second generation antipsychotics.