Synthesis, characterization, DNA binding, topoisomerase I inhibition and antimicrobial activity of four novel zinc(II) fenamates
Abstrakt
Four novel Zn(II) complexes containing fenamic acid (Hfen), a precursor of non-steroidal anti-inflammatory drugs (NSAIDs), and different coligands namely methanol, N,N,N',N'-tetramethylethylene diamine (tmen), N,N'-bis(3-aminopropyl)ethylenediamine (bapen) and 14,811-tetraazacyclotetradecane (cyclam) were prepared in crystalline form. The composition of the complexes was determined by infrared spectroscopy, elemental and thermal analyses.
Results of single-crystal X-ray structure analysis have revealed that while complex 1 is composed of trinuclear [Zn-3(fen)(6)(MeOH)(2)] molecules, the three remaining complexes 2-4 are mononuclear with composition [Zn(fen)(2)(tmen)] (2), [Zn(bapen)(fen)]fen (3), and [Zn (cyclam)(fen)(2)] (4). Binding of all prepared complexes to calf thymus DNA was investigated using UV-vis, fluorescence and circular dichroism (CD) measurements.
In addition, inhibition activity of complexes against topoisomerase I along with antimicrobial activity was determined.