Abstract
Lyme borreliosis is a bacterial infection transmitted by ticks that affects various organs and tissues. Diagnostic difficulty is caused mainly by diversity of clinical manifestations and low availability and applicability of direct laboratory methods.
Identification of specific IgM and IgG antibodies is still the basis of laboratory diagnostics nowadays. However, serological tests merely confirm contact with the disease, but do not correlate with activity of the infection.
To make the right diagnosis, thorough evaluation of the clinical manifestation as well as laboratory results is necessary. Tetracyclines, penicillins, cephalosporins and macrolides are the main groups of antibiotics effective against Lyme disease.
Unsatisfactory clinical response to antibiotic treatment should lead to reevaluation of the diagnosis and consideration of other, non-infectious causes of the symptoms. Repeating or prolonging of the antibiotic treatment is not recommended.