Abstract
This article deals with a biological treatment of psoriasis and of its extracutaneous manifestations. Biologicals are the agents of choice for patients with severe psoriasis and its extracutaneous manifestations like psoriatic arthritis or nail involvement.
The mechanism of action of the biologics is based on suppression of inflammation targeting substances of key importance for inflammatory cascades. This article also focuses on the assessment of effectiveness and safety of adalimumab treatment of psoriasis in both clinical trials and our own clinical practice.
Adalimumab exerts a positive effect on the psoriatic skin, nail, scalp, and joint involvement. Last but not least, improvement of symptoms is reflected in enhanced quality of life of the patients.