Effectiveness and safety of abiraterone acetate treatment for metastatic castration-resistant prostate cancer post-chemotherapy
Abstract
Castration resistant prostate cancer (CRPC) is an advanced stage of this disease with a significant impact on patients quality of lifeand unfavourable prognosis. Docetaxel chemotherapy is considered a standart treatment.
Further treatment options in case ofdisease progression after chemotherapy are very limited. Cytochrome P-450 c17 inhibitor, abiraterone acetate (AA) is a novel drugused in second line treatment of CRPC.
In this article we present results of international clinical studies evaluating efficiency andsafety of AA treatment. According to these studies AA together with prednisone significantly improves median overall survival,time to prostate-specific antigen (PSA) progression and radiological progression, in comparison with prednisone alone.
Treatmentwith AA and prednisone in metastatic CRPC has good efficacy with favourable safety profile.