Abstrakt
Cytoprotector amifostine (AMI) was given in a dose of 50, 100 or 150mg/kg ip in rats treated with several highly toxic doses of T-2 toxin. The best survival rate (24h and 7days after treatment) was obtained with AMI50 (50mg/kg ip).
After T-2 intoxication, a peak in the mean number of gastric lesions (petechiae and ulcerations) was reached on the third day (26.40 +/- 6.24). Administration of AMI50 reduced, almost completely, the total number of gastric lesions in rats acutely poisoned by 0.5 LD50 T-2 (1.5mg/kg sc), starting with day 1 after intoxication (5.60 +/- 3.42).