Abstract
C3 glomerulopathy is a differentially, diagnostically newly defined rare clinical entity with poor prognosis. Symptomatology is variable, the diagnosis is based on the results of immunofluorescent evaluation of renal biopsy, and the disease is confirmed by genetic testing and complete examination of the complement system.
The accumulation of isolated C3 deposits without antibodies is a key histological finding. We report two female patients with the same diagnosis and a relatively different course of disease.
One patient is a heterozygous carrier of rare (p.A353V) and common (PCPggaac) mutation.