Tumor-related Perfusion Changes in White Matter Adjacent to Brain Tumors: Pharmacodynamic Analysis of Dynamic 3T Magnetic Resonance Imaging
Abstract
BACKGROUND/AIM: To verify perfusion differences in white matter adjacent to glioblastomas and metastatic tumors in dynamic contrast-enhanced (DCE) 3T-magnetic resonance imaging (MRI) using gradient echo (GRE) T1 techniques. MATERIALS AND METHODS: A retrospective comparative study was carried out on adults with glioblastoma (n=67) and brain metastases (n=31).
In each patient, conventional 3T-MRI and DCE-MRI with 25 acquisitions of GRE-T1 were performed. The initial area under the contrast-uptake curve (iAUC) and transfer constant (K trans ) in peritumoral regions of the white matter were evaluated using T1 pharmacodynamic modeling software.
RESULTS: Statistically significantly higher relative iAUC (p<0.001) and K trans (p<0.01) values were recorded for peritumoral white matter near glioblastomas compared to that near metastases: 2.29 (SD=1.11) and 2.12 (SD=1.05) vs. 0.96 (SD=0.31) and 1.18 (SD=0.35), respectively. CONCLUSION: In comparison to K trans , the iAUC obtained by DCE-MRI is more suitable for assessing glioblastomas because it better reflects pharmacokinetic peritumoral changes.
Increased iAUC in white matter near to tumor generally indicates glioblastoma, however, a low level does not exclude it. Copyright(C) 2018, International Institute of Anticancer Research (Dr.
George J. Delinasios), All rights reserved.