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Micro-CT in tissue engineering scaffolds designed for bone regeneration: principles and application

Publication at Faculty of Medicine in Pilsen, First Faculty of Medicine |
2018

Abstract

Micro-CT (micro-computed tomography) is a modern preclinical imaging method allowing non-destructive visualizations and structure analysis yielding at a resolution of a few micrometres. Tissue engineering scaffolds are a promising treatment for bone defects.

Micro-CT application for the evaluation of tissue engineering scaffolds for bone surgery and traumatology application is increasing, which comprises in vitro, in vivo and ex vivo studies. Micro-CT itself is not able to replace conventional approaches completely, such as scanning electron microscopy (SEM) or histological examination, but it may offer important benefits regarding non-destructive approach, direct 3D model structure analysis, and visualization and time efficacy.

The overview presented herein focuses on a micro-CT application in the field of tissue engineering scaffolds aimed at bone regeneration.