Histology of intestinal anastomosis - rabbits 2016 (No biomaterial) and rabbits 2018 (PVA and Chitosan)- quantitative histological assessment
Abstract
The aim was to compare the microscopic structure of intestinal anastomosis supported by two types of biomaterials labelled PVA and Chitosan (experiments performed in 2018) with samples containing no biomaterials (experiments performed in 2016). The samples from the PVA group as well as the samples from the Chitosan group contained inflammatory infiltrates that were mostly free of bacteria.
Anastomoses healing with Chitosan had a greater fraction of myofibroblasts, a greater fraction of collagen, and a greater density of microvessels than the samples with no biomaterial added. Anastomoses healing with PVA had a greater densiyty of microvessels than the samples with no biomaterial added.Anastomoses healing with Chitosan contained more collagen, a greater density of microvessels, and had a tendency towards containing more contractile myofibroblasts than the anastomoses healing with PVA.